Graft‐induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
Identifieur interne : 001645 ( Main/Exploration ); précédent : 001644; suivant : 001646Graft‐induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
Auteurs : Marios Politis [Royaume-Uni] ; Wolfgang H. Oertel [Allemagne] ; Kit Wu [Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; Oliver Pogarell [Allemagne] ; David J. Brooks [Royaume-Uni] ; Anders Bjorklund [Suède] ; Olle Lindvall [Suède] ; Paola Piccini [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Brain Mapping, Brain Tissue Transplantation (adverse effects), Corpus Striatum (drug effects), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (pharmacokinetics), Dopamine, Dopamine Plasma Membrane Transport Proteins (metabolism), Dyskinesia, Dyskinesias (etiology), Dyskinesias (pathology), Dyskinesias (radionuclide imaging), Functional Laterality, Graft, Humans, Longitudinal Studies, Male, Middle Aged, Nervous system diseases, Parkinson, Parkinson Disease (pathology), Parkinson Disease (surgery), Parkinson disease, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins (metabolism), Serotonin transporter, Time Factors, Tomography, Emission-Computed, Single-Photon, Transplantation, Tropanes (pharmacokinetics), dyskinesias, serotonin transporter; dopamine transporter, transplantation.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- adverse effects : Brain Tissue Transplantation.
- drug effects : Corpus Striatum.
- etiology : Dyskinesias.
- metabolism : Corpus Striatum, Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- pathology : Dyskinesias, Parkinson Disease.
- chemical , pharmacokinetics : Dihydroxyphenylalanine, Tropanes.
- radionuclide imaging : Corpus Striatum, Dyskinesias.
- surgery : Parkinson Disease.
- Brain Mapping, Functional Laterality, Humans, Longitudinal Studies, Male, Middle Aged, Positron-Emission Tomography, Time Factors, Tomography, Emission-Computed, Single-Photon.
Abstract
Graft‐induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF‐medication graft‐induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single‐photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5‐HT1A agonist suppressed graft‐induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft‐induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft‐induced dyskinesias. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23743
Affiliations:
- Allemagne, Royaume-Uni, Suède
- Angleterre, Bavière, District de Giessen, District de Haute-Bavière, Grand Londres, Hesse (Land)
- Londres, Marbourg, Munich
- Université Louis-et-Maximilien de Munich
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Le document en format XML
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Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Wu, Kit" sort="Wu, Kit" uniqKey="Wu K" first="Kit" last="Wu">Kit Wu</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Sciences Center, Medical Research Council, Hammersmith Hospital, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Ludwig‐Maximilian‐University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1997">1997</biblScope><biblScope unit="page" to="2003">2003</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">18EE56D4C431BCFCA2CE9F0A0F6D9A9CE2E412F4</idno><idno type="DOI">10.1002/mds.23743</idno><idno type="ArticleID">MDS23743</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Mapping</term><term>Brain Tissue Transplantation (adverse effects)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (pharmacokinetics)</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Dyskinesia</term><term>Dyskinesias (etiology)</term><term>Dyskinesias (pathology)</term><term>Dyskinesias (radionuclide imaging)</term><term>Functional Laterality</term><term>Graft</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (surgery)</term><term>Parkinson disease</term><term>Positron-Emission Tomography</term><term>Serotonin Plasma Membrane Transport Proteins (metabolism)</term><term>Serotonin transporter</term><term>Time Factors</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Transplantation</term><term>Tropanes (pharmacokinetics)</term><term>dyskinesias</term><term>serotonin transporter; dopamine transporter</term><term>transplantation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Brain Tissue Transplantation</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term><term>Functional Laterality</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Time Factors</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Dyskinésie</term><term>Greffe</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Transplantation</term><term>Transporteur sérotonine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Graft‐induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF‐medication graft‐induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single‐photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5‐HT1A agonist suppressed graft‐induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft‐induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft‐induced dyskinesias. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Bavière</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Hesse (Land)</li></region><settlement><li>Londres</li><li>Marbourg</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Politis, Marios" sort="Politis, Marios" uniqKey="Politis M" first="Marios" last="Politis">Marios Politis</name></region><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name><name sortKey="Politis, Marios" sort="Politis, Marios" uniqKey="Politis M" first="Marios" last="Politis">Marios Politis</name><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><name sortKey="Wu, Kit" sort="Wu, Kit" uniqKey="Wu K" first="Kit" last="Wu">Kit Wu</name><name sortKey="Wu, Kit" sort="Wu, Kit" uniqKey="Wu K" first="Kit" last="Wu">Kit Wu</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name></region><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name></country><country name="Suède"><noRegion><name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Bjorklund">Anders Bjorklund</name></noRegion><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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